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Butyr fentanyl is a potent short-acting synthetic opioid analgesic drug. It is an analog of fentanyl with around one quarter of its potency. Also, one of the first mentions of this drug can be found in document written by the College on Problem of Drug Dependence, where they mention it as N-butyramide fentanyl analog, this document states that the article describing its clinical effects was published in 1987. It is an agonist for the μ-opioid receptors.
Side effects of fentanyl analogs are similar to those of fentanyl itself. They include itching, nausea, and potentially serious respiratory depression which can be life-threatening. Also, fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics. Also, since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives keep appearing. Fentanyl has entered the market and its demand has risen continuously in time.
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The studies in inhibition studies on binding affinity achieved the same order of analogues. It means that butyrfentantyl is a less potent opioid-agonist than fentanyl. On the other side, during in vitro studies of cross-reactivity with the fentanyl antibody between fentanyl and the fentanyl analogs examined. Revealed order: fentanyl = butyrylfentanyl > (±)-cis–3-methylfentanyl > benzylfentanyl > alpha-methylfentanyl.
Furthermore, the opioid receptor affinity of fentanyl and its analogs was determined from their inhibitory potency in a binding assay with [3H] fentanyl as the radioligand. The Ki value for butyrfentanyl was Ki=32 ± 4.1 nM. Comparing to fentanyl’s Ki (Ki=1.06 ± 0.15 nM), butyrfentanyl’s ability to displace [3H] fentanyl is low and it requires high concentrations of the drug. Buy butyr at our store at a discount. We do discreet shipping to your destination.